New York will clinch a berth in the Audi 2021 MLS Cup Playoffs IF:
- New York win or tie vs. Nashville
 
or:
- Montréal lose or tie vs. Orlando AND
 - D.C. lose or tie vs. Toronto AND
 - Columbus lose or tie vs. Chicago
 
or:
- Montréal lose or tie vs. Orlando AND
 - D.C. lose or tie vs. Toronto AND
 - New York win goal differential vs. Columbus
 
New York will clinch a top-four seed in Eastern Conference IF:
- New York win vs. Nashville AND
 - New York City lose vs. Philadelphia AND
 - Atlanta lose or tie vs. Cincinnati AND
 - Orlando lose or tie vs. Montréal AND
 - New York win goal differential vs. New York City
 

              

