Columbus will clinch a berth in the Audi 2021 MLS Cup Playoffs IF:
- Columbus win vs. Chicago AND
 - New York lose vs. Nashville AND
 - Montréal lose or tie vs. Orlando AND
 - D.C. lose or tie vs. Toronto AND
 - Columbus win goal differential vs. New York
 
Columbus will clinch a berth in the Audi 2021 MLS Cup Playoffs IF: